QM, conservation of Energy and Mutation
It has been suggested in some quarters that quantum mechanical effects might provide explanations for consciousness and a "hand which guides evolution."
Wilson's article in The Volitional Brain (Libet, et. al.) showed that the QM effects required to allow mind-body interaction proposed by its proponents would need be of a magnitude which would violate conservation of energy.
An analysis along these lines with regard to the mechanisms of mutation might prove profitable.
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